Publications

Papers

Publications list and link in PubMed:

https://www.ncbi.nlm.nih.gov/myncbi/1-u408cWsrfk-/bibliography/public/

*Co-corresponding

You can click on the icons to view the abstracts on the bioRxiv or PubMed websites or click on the PDF icon to download the paper/preprint.

Sonia Bolshakova, Sheyla E Carmen Sifuentes, Rhushikesh A Phadke, Alison Brack, PaigeCaley, Caroline Dias, Alberto Cruz Martín. Increased Complement C4 in a Sparse Neuronal Subset Induces Network-Wide Transcriptomic Alterations in the Prefrontal Cortex. bioRxiv 2025.05.29.656749; doi: https://doi.org/10.1101/2025.05.29.656749

Phadke RA, Brack A, Fournier LA, Kruzich E, Sha M, Picard I, Johnson C, Stroumbakis D, Salgado M, Yeung C, Escude Velasco B, Liu YY, Cruz-Martín A.The schizophrenia risk gene C4 induces pathological synaptic loss by impairing AMPAR trafficking. Mol Psychiatry (2024). https://doi.org/10.1038/s41380-024-02701-7.

Graphical Abstract, Fournier et al 2024, iScience

Fournier LA, Phadke RA, Salgado M, Brack A, Nocon JC, Bolshakova S, Grant JR, Padró Luna NM, Sen K, Cruz-Martín A. Overexpression of the schizophrenia risk gene C4 in PV cells drives sex-dependent behavioral deficits and circuit dysfunction. iScience. 2024 Aug 30;27(9):110800. doi: 10.1016/j.isci.2024.110800. PMID: 39310747; PMCID: PMC11416532.

Phadke RA, Wetzel AM, Fournier LA, Brack A, Sha M, Padró-Luna NM, Williamson R, Demas J, Cruz-Martín A. REVEALS: an open-source multi-camera GUI for rodent behavior acquisition. Cereb Cortex. 2024 Oct 3;34(10):bhae421. doi: 10.1093/cercor/bhae421. PMID: 39420472; PMCID: PMC11486610.

Leman DP, Chen IA, Bolding KA, Tai J, Wilmerding LK, Gritton HJ, Cohen Y, Yen WW, Perkins LN, Liberti III WA, Kilic K, Han X, Cruz-Martín A, Gardner TJ, Otchy TM, Davison. IG. Large-scale cellular-resolution imaging of neural activity in freely behaving mice bioRxiv [Preprint]. 2021 Jan 17. doi: 10.1101/2021.01.15.426462.

Kruzich E, Phadke RA, Brack A, Stroumbakis D, Infante O, Cruz-Martín A. A pipeline for STED super-resolution imaging and Imaris analysis of nanoscale synapse organization in mouse cortical brain slices. STAR Protoc. 2023 Nov 8;4(4):102707. doi: 10.1016/j.xpro.2023.102707. Epub ahead of print. PMID: 37948187.

Johnson C, Kretsge LN, Yen WW, Sriram B, O'Connor A, Liu RS, Jimenez JC, Phadke RA, Wingfield KK, Yeung C, Jinadasa TJ, Nguyen TPH, Cho ES, Fuchs E, Spevack ED, Velasco BE, Hausmann FS, Fournier LA, Brack A, Melzer S, Cruz-Martín A. Highly unstable heterogeneous representations in VIP interneurons of the anterior cingulate cortex. Mol Psychiatry. 2022 May;27(5):2602-2618. doi: 10.1038/s41380-022-01485-y. Epub 2022 Mar 4. PMID: 35246635. (bioRxiv, 2020).

Zheng S, Xiao S, Kretsge L, Cruz-Martín A, Mertz J. Depth resolution in multifocus laser speckle contrast imaging. Opt Lett. 2021 Oct 1;46(19):5059-5062. doi: 10.1364/OL.436334. PMID: 34598268; PMCID: PMC9801310.

Borrelli KN, Yao EJ, Yen WW, Phadke RA, Ruan QT, Chen MM, Kelliher JC, Langan CR, Scotellaro JL, Babbs RK, Beierle JC, Logan RW, Johnson WE, Wachman EM, Cruz-Martín A, Bryant CD. Sex Differences in Behavioral and Brainstem Transcriptomic Neuroadaptations following Neonatal Opioid Exposure in Outbred Mice. eNeuro. 2021 Sep 20;8(5):ENEURO.0143-21.2021. doi: 10.1523/ENEURO.0143-21.2021. PMID: 34479978; PMCID: PMC8454922.

Cover in Plos Biology, Comer et al., 2020

Comer AL, Jinadasa T, Sriram B, Phadke RA, Kretsge LN, Nguyen TPH, Antognetti G, Gilbert JP, Lee J, Newmark ER, Hausmann FS, Rosenthal S, Liu Kot K, Liu Y, Yen WW, Dejanovic B, Cruz-Martín A. Increased expression of schizophrenia-associated gene C4 leads to hypoconnectivity of prefrontal cortex and reduced social interaction. PLoS Biol. 2020 Jan 14;18(1):e3000604. doi: 10.1371/journal.pbio.3000604. PMID: 31935214; PMCID: PMC6959572. (Cover)(bioRxiv, 2019).

Comer AL, Carrier M, Tremblay MÈ, Cruz-Martín A. The Inflamed Brain in Schizophrenia: The Convergence of Genetic and Environmental Risk Factors That Lead to Uncontrolled Neuroinflammation. Front Cell Neurosci.2020 Aug 27;14:274. doi: 10.3389/fncel.2020.00274. PMID: 33061891; PMCID: PMC7518314.

Comer AL, Sriram B, Yen WW, Cruz-Martín A. A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior. J Vis Exp. 2020 May 21;(159). doi: 10.3791/61350. PMID: 32510510.

Sriram B, Li L, Cruz-Martín A, Ghosh A. A Sparse Probabilistic Code Underlies the Limits of Behavioral Discrimination. Cereb Cortex. 2020 Mar 14;30(3):1040-1055. doi: 10.1093/cercor/bhz147. PMID: 31403676; PMCID: PMC7132908.

Shen J, Blute TA, Liberti WA, Yen WWUG, Cruz-Martín A*, Gardner TJ* (2017). Songbird organotypic culture as an in-vitro model for interrogating sparse sequencing networks. BioRxiv doi: https://doi.org/10.1101/164228

Cover in Nature, Cruz-Martin et al., 2014

UCSD Postdoc (With Anirvan Ghosh and Andrew Huberman)

Cruz-Martín A, El-Danaf RN, Osakada F, Sriram B, Ghosh A, Dhande O, Nguyen P, Huberman AD (2014). A dedicated circuit linking direction-selective retinal ganglion cells to primary visual cortex. Nature 507: 358-361 (Cover).

Cruz-Martín A, Huberman AD. Visual cognition: rats compare shapes among the crowd. Curr Biol. 2012 Jan 10;22(1):R18-20. doi: 10.1016/j.cub.2011.11.047. PMID: 22240473; PMCID: PMC3513354.

Cover in Journal of Neuroscience, Cruz-Martin et al., 2010

UCLA Postdoc (With Carlos Portera-Cailliau)

Cruz-Martín A, Crespo M, Portera-Cailliau C. Glutamate induces the elongation of early dendritic protrusions via mGluRs in wild type mice, but not in fragile X mice. PLoS One. 2012;7(2):e32446. doi: 10.1371/journal.pone.0032446. Epub 2012 Feb 27. PMID: 22384253; PMCID: PMC3288094.

Cruz-Martín A, Crespo M, Portera-Cailliau C. Delayed stabilization of dendritic spines in fragile X mice. J Neurosci. 2010 Jun 9;30(23):7793-803. doi: 10.1523/JNEUROSCI.0577-10.2010. PMID: 20534828; PMCID: PMC2903441.

Chowdhury TG, Jimenez JC, Bomar JM, Cruz-Martin A, Cantle JP, Portera-Cailliau C. Fate of cajal-retzius neurons in the postnatal mouse neocortex. Front Neuroanat. 2010 Mar 3;4:10. doi: 10.3389/neuro.05.010.2010. PMID: 20339484; PMCID: PMC2845061.

Cover in Nature Neuroscience, Sippy et al., 2003

UCLA PhD (With Felix E. Schweizer)

Cruz-Martín A, Schweizer FE. Imbalance between excitation and inhibition among synaptic connections of CA3 pyramidal neurons in cultured hippocampal slices. Eur J Neurosci. 2008 Mar;27(6):1353-63. doi: 10.1111/j.1460-9568.2008.06106.x. Epub 2008 Mar 7. PMID: 18331341; PMCID: PMC3132580.

Sippy T, Cruz-Martín A, Jeromin A, Schweizer FE. Acute changes in short-term plasticity at synapses with elevated levels of neuronal calcium sensor-1. Nat Neurosci. 2003 Oct;6(10):1031-8. doi: 10.1038/nn1117. Epub 2003 Aug 31. PMID: 12947410; PMCID: PMC3132582.(Cover).

Cruz-Martín A, Mercado JL, Rojas LV, McNamee MG, Lasalde-Dominicci JA. Tryptophan substitutions at lipid-exposed positions of the gamma M3 transmembrane domain increase the macroscopic ionic current response of the Torpedo californica nicotinic acetylcholine receptor. J Membr Biol. 2001 Sep 1;183(1):61-70. doi: 10.1007/s00232-001-0051-z. PMID: 11547353; PMCID: PMC4586063.

Book Chapters

Cruz-Martín A, Portera-Cailliau C (2014). In vivo imaging of axonal and dendritic structures in neonatal mouse cortex. In Imaging in Developmental Biology: A Laboratory Manual. Cold Spring Harb Protoc 57-64. doi: 10.1101/pdb.prot080150 (Book chapter).