We are currently seeking students and postdocs to lead long-term projects in the lab.
Super-resolution imaging (click on the image to play the movie)
Welcome to the Cruz-Martin Neural Circuits Lab. Our lab is dedicated to advancing our understanding of neural circuitry and its implications for brain health and disease. Joining our lab means becoming part of a dynamic and collaborative team passionate about uncovering the molecular and cellular mechanisms that govern neural connectivity. Students and postdocs will have the opportunity to work with cutting-edge technologies and methodologies, such as in vivo imaging, super-resolution microscopy, and optogenetics. Our research aims to make groundbreaking discoveries that can pave the way for developing novel therapies for neuropsychiatric disorders and neurodegenerative diseases. We welcome motivated individuals at all career stages to contribute to our mission of pushing the boundaries of neuroscience and making a lasting impact on human health.
The Cruz-Martín Lab's research is focused on understanding how immune genes and inflammation affect brain connectivity during development and in neurodegenerative diseases. The lab uses advanced techniques such as molecular tools, in vivo imaging with 1P and 2P miniscopes, super-resolution microscopy, electrophysiology, and machine learning to unravel the biological mechanisms underlying synaptic plasticity and pathology. Research targets include the role of immune molecules like complement component 4 (C4) in synaptic connectivity and the effects of neuroinflammation on brain circuits implicated in disorders like schizophrenia and Alzheimer's Disease. Through innovative approaches and interdisciplinary collaboration, the Cruz-Martin Lab aims to discover new therapeutic targets for neuropsychiatric and neurodegenerative diseases.
1P Miniscopes
The Cruz-Martín lab is conducting cutting-edge research on the role of recently identified schizophrenia (SCZ)-associated genes in the development and function of the cortex. They are using advanced techniques such as the RNAscope HiPlex v2 assay and Slide-seqV2 to understand how early life stressors impact the prefrontal cortex (PFC) at the molecular level. Additionally, the lab is creating a detailed spatial map of SCZ genes and cell types in the developing mouse and human brain. To study the behavioral effects of early life stress in mice, the lab is using tools like DeepLabCut for behavioral tracking and REVEALS, a custom GUI for collecting rodent behavioral data.
If you are interested in doing research in the Cruz-Martin Neural Circuits lab, please get in touch with Dr. Alberto Cruz-Martin at [email protected]. We are currently hiring at all levels.
If you are interested in doing research in the Cruz-Martin Neural Circuits lab, please get in touch with Dr. Alberto Cruz-Martin at [email protected]. We are currently hiring at all levels.
Whole-Cell Patch-Clamp Electrophysiology
The Cruz-Martin lab, located in the Department of Anesthesiology at the University of Colorado School of Medicine, provides an outstanding environment for conducting cutting-edge research. The University of Colorado School of Medicine is well-known for its advanced facilities, interdisciplinary collaboration, and strong focus on translational research. Researchers have access to state-of-the-art technologies, comprehensive support services, and a lively scientific community that promotes innovation and discovery. The school's dedication to research excellence is demonstrated through its numerous research centers and institutes, offering abundant opportunities for collaboration and knowledge sharing. Furthermore, its Colorado location provides an inspiring setting for scientific exploration, with a supportive and friendly atmosphere that encourages researchers to push the boundaries of their fields.
One of the primary areas of research in the Cruz-Martin lab involves studying the pathological mechanisms of
neuroinflammation and its impact on neuronal connectivity (Comer et al., 2020).
neuroinflammation and its impact on neuronal connectivity (Comer et al., 2020).
Endogenous C4 in neurons stained with an antibody